Dendrites of dentate gyrus granule cells contribute to pattern separation by controlling sparsity
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منابع مشابه
Dendrites of dentate gyrus granule cells contribute to pattern separation by controlling sparsity
The hippocampus plays a key role in pattern separation, the process of transforming similar incoming information to highly dissimilar, nonverlapping representations. Sparse firing granule cells (GCs) in the dentate gyrus (DG) have been proposed to undertake this computation, but little is known about which of their properties influence pattern separation. Dendritic atrophy has been reported in ...
متن کاملDendrites of DG granule cells contribute to pattern separation by controlling sparsity
6 Crete 7. CC-BY-NC 4.0 International license not peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was. Abstract 8 The hippocampus plays a key role in pattern separation, namely the process of transforming 9 similar incoming information to highly dissimilar, non-overlapping representations. Sparse 10 firing granule cells in the dent...
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Adult-born granule cells (GCs), a minor population of cells in the hippocampal dentate gyrus, are highly active during the first few weeks after functional integration into the neuronal network, distinguishing them from less active, older adult-born GCs and the major population of dentate GCs generated developmentally. To ascertain whether young and old GCs perform distinct memory functions, we...
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INTRODUCTION The dentate gyrus (DG) is postulated to be a “pattern separator” (Marr, 1971; Rolls, 1989a,b, 1990; Treves and Rolls, 1994). Yet, the definition of pattern separation has become a haze, with researchers using the term interchangeably to describe computational processes, changes in cell ensemble activity, and even behavioral phenomena (Leutgeb et al., 2007; McHugh et al., 2007; Clel...
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Granule cells of the mammalian dentate gyrus normally form a discrete layer, and virtually all granule cells migrate to this location. Exceptional granule cells that are positioned incorrectly, in 'ectopic' locations, are rare. Although the characteristics of such ectopic granule cells appear similar in many respects to granule cells located in the granule cell layer, their rare occurrence has ...
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ژورنال
عنوان ژورنال: Hippocampus
سال: 2016
ISSN: 1050-9631
DOI: 10.1002/hipo.22675